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N-Substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors
D. Rakowitz 1, A. Gmeiner 1, B. Matuszczak 2
Affiliations
Article Info
1 Institute of Pharmacy, Leopold-Franzens University of Innsbruck, Innsbruck, Austria
2 Institute of Pharmacy, Leopold-Franzens University of Innsbruck, Innrain 52a, Innsbruck, A-6020, Austria, Email: barbara.matuszczak@uibk.ac.at
Abstract
Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.