Die Pharmazie is published by IMR Press from Volume 81 Issue 1 (2026). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Preparation and application of a novel Pirkle-type chiral stationary phase in liquid chromatography
Dandan Zhang 1, Famei Li 2, Myung Ho Hyun 3
Affiliations
Article Info
1 Department of Analytical Chemistry, Shenyang Pharmaceutical University, Wenhua road 103, Shenyang, China, Email: Dandanzhang625@hotmail.com
2 Department of Analytical Chemistry, Shenyang Pharmaceutical University, Shenyang, China
3 Department of Chemistry and Chemistry Institute for Functional Materials, Busan National University, Busan, Korea
Abstract
A new high-performance liquid chromatographic Pirkle-type chiral stationary phase (CSP) was prepared starting from R-(+)-1,1′-binaphthyl-2,2′-diamine. The CSP prepared was successfully applied in resolving various N-(3,5-dinitrobenzoyl)-α-amino amides and N-acyl-1-aryl-1-aminoalkanes and found to be effective. The chiral recognition mechanism was proposed to be π-π interaction and simultaneously hydrogen bonding interactions between the CSP and the analytes.