Background: There are current clinical observations that atorvastatin
may promote subdural hematoma resorption. We aimed to assess the causal effects
of lipid-lowering agents 3-hydroxy-3-methylglutaryl coenzyme A reductase
(HMGCR) inhibitors, Proproteinconvertase subtilisin/kexin type
9 (PCSK9) inhibitors and Niemann-Pick C1-like protein 1
(NPC1L1) inhibitors on traumatic subdural hematomas. Methods:
We used genetic instruments to proxy lipid-lowering drug exposure, with genetic
instruments being genetic variants within or near low-density lipoprotein (LDL
cholesterol)-associated drug target genes. These were analyzed by using a
two-sample Mendelian randomization (MR) study. Results: A causal
relationship was found between HMGCR inhibitors and traumatic subdural
hematoma (Inverse variance weighted (
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Original Research
Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study
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1
Department of Neurosurgery, Xiang’an Hospital of Xiamen University, 361100 Xiamen, Fujian, China
2
Department of Ultrasound, Maternal and Child Health Hospital of Fujian Province, 350005 Fuzhou, Fujian, China
3
Department of Hepatobiliary Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, 361000 Longyan, Fujian, China
4
Department of Otolaryngology-Head and Neck Surgery, Xiang’an Hospital of Xiamen University, 361100 Xiamen, Fujian, China
5
Department of Neurosurgery, Fuzong Clinical Medical College of Fujian Medical University (The 900th Hospital of Joint Logistic Team of PLA), 350025 Fuzhou, Fujian, China
*Correspondence: wlf74@163.com (Liangfeng Wei)
J. Integr. Neurosci. 2024, 23(4), 76;
https://doi.org/10.31083/j.jin2304076
Submitted: 30 June 2023 | Revised: 20 September 2023 | Accepted: 7 October 2023 | Published: 10 April 2024
(This article belongs to the Special Issue Traumatic Brain Injury: Mechanisms of Pathogenesis and Therapeutic Interventions)
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
lipid-lowering drugs
traumatic subdural hemorrhage
mendelian randomization analysis
cause-and-effect relationship
drug targeting
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Fig. 1.