IMR Press / JIN / Volume 22 / Issue 2 / DOI: 10.31083/j.jin2202047
Open Access Original Research
Efficacy of Long-Term Spinal Nerve Posterior Ramus Pulsed Radiofrequency in Treating Subacute Herpetic Neuralgia: A Prospective Randomized Controlled Trial
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1 Department of Pain, Guizhou Provincial People's Hospital, 550002 Guiyang, Guizhou, China
2 Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, Guizhou, China
3 Department of Pain, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, Guizhou, China
4 Department of Pain, The Affiliated Hospital of Guizhou Medical University, 550004 Guiyang, Guizhou, China
*Correspondence: (Jinfeng Zou)
These authors contributed equally.
J. Integr. Neurosci. 2023, 22(2), 47;
Submitted: 29 September 2022 | Revised: 8 November 2022 | Accepted: 10 November 2022 | Published: 28 February 2023
(This article belongs to the Special Issue Sense Disorders in Neuroinflammatory and Neurodegenerative Disease)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Objective: This study aimed to observe the clinical efficacy of long-term spinal nerve posterior ramus pulsed radiofrequency (PRF) in treating subacute herpes zoster neuralgia (HZN). Methods: A total of 120 patients with subacute HZN in the thoracolumbar region and back were equally randomized to the conventional PRF group (P group, n = 60), with a pulse of 180 s, or to the long-term PRF group (LP group, n = 60), with a pulse of 600 s. The patients’ baseline characteristics, the incidence rate of postherpetic neuralgia (PHN), and the dose of analgesics were compared between the two groups. Results: Based on the pain-rating index (PRI), the PRI-sensory, PRI-affective, visual analogue scale, and present pain intensity scores in the two groups were lower at T2, T3, and T4 time points than at the T1 time point after treatment (p < 0.05). After 2 months, the dose of analgesics was significantly lower in the LP group than in the P group (p < 0.05), and the incidence of PHN was considerably lower. Conclusions: Long-term spinal nerve posterior ramus PRF is a more effective treatment strategy for subacute HZN than conventional PRF. It can effectively prevent the occurrence of PHN.

long-term pulsed radiofrequency
postherpetic neuralgia
pulsed radiofrequency
subacute herpes zoster neuralgia
gzwkj2021-284/Guizhou Provincial Health Commission
202042940112211125/Basic Research Program of Guizhou Provincial Science and Technology Department
Fig. 1.
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