IMR Press / JIN / Volume 21 / Issue 6 / DOI: 10.31083/j.jin2106159
Open Access Original Research
The Evaluation Indexes Suitable for Nonhuman Primates can be Extracted from Clinical Consciousness Disorder Assessment Scales: A Hypothesis
Wei-ming Sun1,2,3,4,*,†Guan-xiu Liu3,4,†Chang-hao Le3,4Can Li1,2Xiang-li Dong4,5Chao-lin Ma1,2,*
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1 School of Life Science, Nanchang University, 330031 Nanchang, Jiangxi, China
2 Institute of Life Science, Nanchang University, 330031 Nanchang, Jiangxi, China
3 Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, 330036 Nanchang, Jiangxi, China
4 Jiangxi Medical College, Nanchang University, 330031 Nanchang, Jiangxi, China
5 Department of Psychosomatic Medicine, The Second Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, China
*Correspondence: sunweiming@email.ncu.edu.cn (Wei-ming Sun); chaolinma@ncu.edu.cn (Chao-lin Ma)
These authors contributed equally.
Academic Editor: Sergio Bagnato
J. Integr. Neurosci. 2022, 21(6), 159; https://doi.org/10.31083/j.jin2106159
Submitted: 22 April 2022 | Revised: 1 June 2022 | Accepted: 9 June 2022 | Published: 21 September 2022
(This article belongs to the Special Issue Disorders of Consciousness: From Pathophysiology to Treatment)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Currently, case studies or clinical trials in different patient populations remain the main resource underlying the understanding of disorder of consciousness (DoC). This provides a low efficacy for the derivation of data and the implementation of associated controlled experimental designs. Preclinical models provide precise controls, reduced variability, rich data output and limited ethical complexity. Nonhuman primates are suitable model animals for disorders of consciousness due to their brain structure being very similar to that of humans. Behavioral tests remain the primary standard for assessing the consciousness status of humans. However, there is currently no behavioral assessment scale available for evaluation of the state of consciousness disorder in nonhuman primates. This presents a significant challenge for the establishment of different models of consciousness disorder. Therefore, there is considerable motivation to focus on the development of a proper tool for assessment of the state of consciousness associated with nonhuman primate models that are based on clinically common consciousness assessment scales. Methods: It is assumed that the Delphi and level analysis methods based on clinical consciousness disorder assessment scales may provide an effective way to select and include assessment indexes for levels of consciousness in nonhuman primates. Results: 8 first-level indicators with 41 second-level indexes were selected preliminary as a pool of evaluation entries of state of consciousness of nonhuman primates. Conclusions: It may be practicable to extract appropriate indicators for non-human primates from the clinical consciousness disorder assessment scales. Besides, a combination of Delphi method, behavioral analysis, electroencephalography, neuroimaging (such as positron emission tomography-computed tomography) and functional magnetic resonance imaging is necessary to test the reliability and validity of the novel scale reported here.

Keywords
assessment scale
disorders of consciousness
nonhuman primates
animal models
Funding
31760276/ National Natural Science Foundation of China
31960171/ National Natural Science Foundation of China
20171BAB204019/ Natural Science Foundation of Jiangxi Province
20192ACB20022/ Natural Science Foundation of Jiangxi Province
YC2021-B021/ Jiangxi Provincial Special Fund for Postgraduate Innovation
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