IMR Press / JIN / Volume 21 / Issue 4 / DOI: 10.31083/j.jin2104109
Open Access Original Research
Panaxydol Derived from Panax notoginseng Promotes Nerve Regeneration after Sciatic Nerve Transection in Rats
Yueming Wang1,2,3,†Jianwen Li4,5,†Yan Wo3,*Zhengrong Zhou1,2,6,*
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1 Department of Radiology, Fudan University Shanghai Cancer Center, 200032 Shanghai, China
2 Department of Oncology, Shanghai Medical College, Fudan University, 200032 Shanghai, China
3 Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China
4 Department of Urology, Dushu Lake Hospital Affiliated to Soochow University, 215100 Suzhou, Jiangsu, China
5 Dushu Lake Branch of The First Affiliated Hospital of Soochow University, 215100 Suzhou, Jiangsu, China
6 Department of Radiology, Minhang Branch of Fudan University Shanghai Cancer Center, 200032 Shanghai, China
*Correspondence: (Yan Wo); (Zhengrong Zhou)
These authors contributed equally.
Academic Editor: Francois Roman
J. Integr. Neurosci. 2022, 21(4), 109;
Submitted: 30 December 2021 | Revised: 22 March 2022 | Accepted: 1 April 2022 | Published: 7 June 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Peripheral nerve regeneration is a coordinated process of Schwann cell (SC) reprogramming and intrinsic neuronal growth program activation. Panaxydol (PND) is a strong biologically active traditional Chinese medicine monomer extracted from Panax notoginseng rhizomes. In vitro, PND protects neurons and SCs from injury and stimulates the expression and secretion of neurotrophic factors (NTFs) by SCs. We hypothesized that PND may also promote peripheral nerve regeneration in adult animals. Methods: PND (10 mg/kg body weight) was injected intraperitoneally into the Sprague–Dawley (SD) rats for two consecutive weeks after sciatic nerve transection. The morphology of the repaired sciatic nerve was evaluated after 16 weeks, and sensory and motor function recovery was evaluated using functional and behavioral techniques. Results: PND was biologically safe at an injection dose of 10 mg/kg/day. After 14 days, it significantly increased the myelination of regenerated nerve fibers, and promoted sensory and motor function recovery. In the early stage of injury, PND significantly upregulated the mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptors in distal injured nerves, which may represent a possible mechanism by which PND promotes nerve regeneration in vivo. Conclusions: Our study demonstrated that PND leads to sensory and motor recovery in a sciatic nerve transection model rat. Furthermore, we showed that BDNF mRNA level was significantly increased in the injured distal nerve, potentially contributing to the functional recovery. Further research is warrantied to examine whether direct injection is a more efficient method to increase BDNF expression compared to an exogenous BDNF administration.

biochemical pharmacology
panaxydol (PND)
traditional Chinese medicine
peripheral nerve regeneration
Schwann cells
nerve growth factor
Fig. 1.
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