IMR Press / JIN / Volume 21 / Issue 3 / DOI: 10.31083/j.jin2103083
Open Access Original Research
Scalp Stimulation Targets for Neurological Conditions—Evidence from Large-Scale Meta-Analyses
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1 Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
*Correspondence: kongj@nmr.mgh.harvard.edu (Jian Kong)
Academic Editor: Rafael Franco
J. Integr. Neurosci. 2022, 21(3), 83; https://doi.org/10.31083/j.jin2103083
Submitted: 11 January 2022 | Revised: 1 March 2022 | Accepted: 3 March 2022 | Published: 15 April 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Neurological disorders are a major source of suffering for patients worldwide. Scalp stimulation methods have been widely applied in treating a number of neurological disorders. Recently, our understanding of pathological mechanisms associated with neurological disorders has been enhanced significantly. Nevertheless, these findings have yet to be well-integrated into scalp stimulation treatments for neurological disorders. Methods: In a previous study, we proposed new brain targets for scalp stimulation in the treatment of eight common mental disorders based on the results of a large-scale meta-analyses using Neurosynth. This study aims to extend our previous findings in identifying surface brain targets for seven common neurological disorders: Alzheimer’s disease, aphasia, chronic pain, dementia, dyslexia, mild cognitive impairment, and Parkinson’s disease, utilizing a similar method. Results: We hidentified seven to eight potential scalp stimulation targets for each disorder and used both 10–20 EEG system and acupuncture points to locate these targets to facilitate its clinical application. Conclusions: The proposed target protocols may facilitate and extend clinical applications of scalp stimulation methods such as transcranial electrical stimulation and scalp acupuncture in the treatment of neurological disorders.

Keywords
meta-analysis
scalp stimulation
brain stimulation transcranial electrical stimulation
scalp acupuncture
neurological disorder
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