Vanillic acid (VA) exhibited antioxidant and neuroprotective properties in some
neurodegenerative disorders. So, the current study examined the neuroprotective
potential of VA as an antiepileptic agent in pentylenetetrazole (PTZ)-induced
epileptic rats and the prospective role of Insulin like growth factor-1 (IGF-1)
and nuclear factor-2 erythroid-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1)
pathway in this respect. Thirty male albino rats were equally subdivided into 3
groups; (1) normal control (NC) group, (2) PTZ-group: received PTZ (50 mg/Kg,
i.p. every other day) for 14 days, and (3) PTZ + VA group: received PTZ and VA (50
mg/Kg daily for 2 weeks). The seizure score and latency were evaluated after PTZ
injection. Also, the markers of oxidative stress (malondialdehyde (MDA),
catalase, and reduced glutathione (GSH)), histopathological examination, the
expression of glial fibrillary acidic protein (GFAP) (a marker of astrocytes)
IGF-1, Nrf2, and HO-1 were assessed in the brain tissues by the end of the
experiment. PTZ caused significant decrease in seizure latency and significant
increase in seizure score by the end of the experiment (p
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Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk
Mahmoud A. El-Hefnawy1, Asmaa Yehia1, Eman M. El Nashar2,3, Somaya Saad1, Walaa Obydah1, Mansour A. Alghamdi2,4, Wardah A. Alasmari5, Abdelaziz M. Hussein1,*
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1
Department of Medical Physiology, Faculty of Medicine, Mansoura University, 35516 Mansoura, Egypt
2
Department of Anatomy, College of Medicine, King Khalid University, 61421 Abha, Saudi Arabia
3
Department of Histology and Cell Biology, Faculty of Medicine, Benha University, 13518 Benha, Egypt
4
Genomics and Personalized Medicine Unit, College of Medicine, King Khalid University, 61421 Abha, Saudi Arabia
5
Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, 21955 Makah, Saudi Arabia
*Correspondence: zizomenna28@yahoo.com; menhag@mans.edu.eg (Abdelaziz M. Hussein)
J. Integr. Neurosci. 2022, 21(1), 15;
https://doi.org/10.31083/j.jin2101015
Submitted: 9 July 2021 | Revised: 26 July 2021 | Accepted: 20 August 2021 | Published: 28 January 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
PTZ-induced epilepsy
Vanillic acid
IGF-1
Nrf2
HO-1
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