The purpose of our research was to evaluate whether ginsenoside Rb1 has neuroprotective effects
against lipopolysaccharide (LPS)-induced brain injury. ICR mice were
intraperitoneally (i.p.) injected with 20 or 40 mg/kg Rb1 or saline for 7
consecutive days. On the 7th day, 30 minutes after Rb1 or saline administration,
a single dose of LPS (LPS group, Rb1+LPS group) or saline (control group) was
injected i.p. into the mice. Results demonstrated that Rb1 treatment could
significantly improve the behavior performance of LPS mice in both the open field
test and the beam walking test. Rb1 can also markedly attenuate the neuronal
lesion in both hippocampus and somatosensory cortex in the brain of LPS mice. In
addition, Rb1 treatment also significantly inhibits the LPS-induced
neuroinflammation in the brain, indicated by reduced reactive microglia and
decreased IL-1