IMR Press / JIN / Volume 20 / Issue 2 / DOI: 10.31083/j.jin2002028
Open Access Original Research
The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface
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1 Laboratory of Medical Cybernetics, Voronezh State University, 394018 Voronezh, Russia
2 V. A. Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, 117997 Moscow, Russia
3 Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia
4 Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia
5 Department of Programming and Information Technologies, Voronezh State University, 394018 Voronezh, Russia
*Correspondence: (Artem P. Gureev)
J. Integr. Neurosci. 2021, 20(2), 287–296;
Submitted: 27 January 2021 | Revised: 5 March 2021 | Accepted: 20 April 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of BDNF when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities.

Video-oculographic interface
Brain-derived neurotrophic factor
Eye movement
Working memory
Fig. 1.
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