International Journal of Pharmacology (IJP) is published by IMR Press from Volume 21 Issue 4 (2025). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Studies of Behavioural and Neural Mechanism of Aridanin Isolated from Tetrapleura tetraptera in Mice
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger-Delta University, Bayelsa State, Nigeria
2 Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife Osun State, Nigeria
3 Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife Osun State, Nigeria
4 Department of Pharmacognosy, Faculty of Pharmacy, Niger-Delta University, Bayelsa, Bayelsa State, Nigeria
Abstract
The aim of the present study was to investigate the central nervous system depressant effect and neural mechanisms of Aridanin in mice. Novelty-induced rearing, head dips, locomotor activity and effect on learning and memory were studied. Aridanin at 5, 10, 20 and 30 mg kg-1 b.wt. reduced novelty-induced rearing and locomotor activity in mice. Head dip reduction was noticed only with the highest dose (30 mg kg-1, i.p.) while in Y-maze, a reduction in number of entrance (locomotion) with no change in percentage alternation on short term working memory was obtained. Aridanin reversed the central excitatory effect of flumazenil in the methods. These results confirm the central depressant properties of Aridanin which may be mediated through GABAA receptor.
Keywords
- Aridanin
- Tetrapleura tetraptera
- Y-maze
- hole board
- open field
- rearing