Metal complexes have been applied as medicinal agents in the treatment of different human infections and diseases. So, the aim of this study is focused on studying the spectroscopic, thermal and evaluating antimicrobial investigations of ibuprofen analgesic drug complexes formulas with Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) metal ions. Complexes of Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) with ibuprofen ligand as to evaluate the biological activity were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV-VIS, IR, 1H-NMR spectroscopy and thermal analysis. The IR spectral data suggested that the ibuprofen ligand behaves as a monobasic bidentate ligand towards the central metal ion with deprotonated of carboxylic group. From the microanalytical data, the stoichiometry of the complexes 1:1, 1:2 and 1:3 (metal: ligand) was found. The metal complexes were screened for antibacterial activity against Gram -ve organisms as Escherichia coli and Pseudomonas aeruginosa, Gram +ve organisms as Bacillus subtilis and Bacillus cereus and antifungal organisms such as Aspergillus niger, Aspergillus flavus and Aspergillus oryzae. The resulted Ibu compounds has proved the thermal stability feature. The antimicrobial activities of the metal complexes of Ibu recorded a significant effect against some bacteria and fungi.