International Journal of Pharmacology (IJP) is published by IMR Press from Volume 21 Issue 4 (2025). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Synthesis and Anti-inflammatory Evaluation of Some New Quinazoline Derivatives
1 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University Cairo, Egypt
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
3 Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
Abstract
A series of new 5-(4-chlorophenyl)-9-iodo-3-substituted-1,2,4-triazolo[4,3-c]quinazoline and 2- (4-chlorophenyl)-6-iodo-4-substituted-quinazoline was prepared via several synthetic routes. Some of the compounds were prepared by cyclization of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with semicarbazide or acid hydrazide; other compounds were obtained from reaction of 2-(4-chlorophenyl)-4-chloro-6-iodoquinazoline with some amines and amino acid esters. The synthesized compounds were evaluated as anti-inflammatory agents through the carrageenin-induced paw edema test. The screening data revealed that nine of the tested compounds have activity comparable to indomethacin.
Keywords
- 1,2,4-triazolo[4,3-c] quinazoline
- synthesis
- anti-inflammatory
- nonsteroidal
- analgesic