Dear Colleagues,

Organoids replicate the morphology, structure, and physiological processes of organs or tissues and are created by in vitro three-dimensional (3D) culturing. There has been growing interest in organoids and spheroids as valuable preclinical models and tools for cancer research and treatment development. Inflammation has many pro-tumorigenic effects on the body including epigenetic reprogramming, DNA damage, promoting hypoxia and angiogenesis, activating cancer-associated fibroblasts, recruiting regulatory immune cells, and inhibiting anti-tumor immune surveillance. Thus, it can act as both an initiator and driver of cancer development. Understanding the role of various inflammatory cell types in the tumor microenvironment over time is crucial to comprehend how inflammation directly or indirectly contributes to cancer development and progression. The aim of this Special Issue is to publish original research as well as comprehensive reviews on recent advances in the field of antitumor approaches. Special emphasis will be placed on recent process using organoids and spheroids for the application of 3D cell culture in cancer therapy.

Alessia Filippone
Guest Editor