Dear Colleagues,

The development of the embryo and its constituent parts encompasses a phenomenon known as morphogenesis. This intricate process is governed by fundamental cellular activities that lead to distinct patterns of growth and shape formation. Disruption in the normal course of differential growth can arise from various factors, such as genetic mutations, exposure to teratogenic agents, or a combination of these processes. These perturbations can culminate in dysmorphogenesis, a phenomenon characterized by irregularities in growth and development, ultimately leading to the manifestation of structural birth defects.

This special issue aims to highlight the significant contributions of animal models, including mice, chicken and zebrafish, to developmental morphogenesis. These models allow scientists to conduct experiments, uncover developmental processes across species, and gain insights into human embryogenesis. Additionally, by studying these models, we gain profound insights into the underlying mechanisms of dysmorphogenesis and the potential for innovative preventive and therapeutic strategies. This issue will compile a diverse range of research articles and reviews, showcasing how animal models serve as powerful tools to explore the mechanisms governing normal development, as well as the complexities of developmental processes gone wrong.

Paschalis Theotokis
Guest Editor