Mitochondrial Transplantation Therapy: A Novel Approach in the Era of Organelle-Centered Regenerative Medicine – Graphical Abstract

The research team consisted of Ha Rim Shin, Gaheon Lee, and Kyung Hwa Kim, affiliated with Dong-A University, Republic of Korea. The article was published in FBL, Volume 30, Issue 8.

This review highlights the emerging concept of mitochondrial transplantation therapy within the framework of organelle-centered regenerative medicine. Particular attention is paid to the unique regulatory roles that mitochondria play in stem cell fate determination, self-renewal and differentiation. By outlining how mitochondria act not only as energy suppliers but also as critical signaling and regulatory hubs, we explore their potential to enhance stem cell-based regenerative strategies. In addition, evidence from preclinical and clinical studies is presented to emphasize the therapeutic potential of mitochondrial transplantation in tissue repair, degenerative disorders, and metabolic diseases.

Overall, this review underscores the promise of organelle-targeted interventions as a novel paradigm in regenerative medicine and provides a framework for future applications of mitochondrial-based therapy.

Read the article:

Mitochondrial Transplantation Therapy: A Novel Approach in the Era of Organelle-Centered Regenerative Medicine: https://doi.org/10.31083/FBL37006

Comparative Analysis of the Bioactivity and Anti-Inflammatory Effects Against Endotoxin in Mitochondria for Transplantation: Impact of Muscle Origin in Rats: https://doi.org/10.31083/FBL37367

The Role of m6A Modification in Regulating MSC Differentiation and Immunomodulation: Implications for Regenerative Medicine and Therapeutic Applications: https://doi.org/10.31083/FBL36475

Inhibition of Galectin-3 Expression Could Preserve the Immunoregulatory Function of Mesenchymal Stem Cells During Cell Passaging: https://doi.org/10.31083/FBL39918