Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Dynisha Ivy 1, Marvin J Robinson 11 Division of Science and Mathematics, Bethune-Cookman College, Daytona Beach, Florida 32114, USA
Abstract
Increased immunoactivity of ε-nitrosolysine was detected in Western blot in peroxynitrite-reacted histones H2A, H3 and H4. The N-nitrosation may be reversible as indicated by the decreased immunoactivity via either subsequent incubation with reduced glutathione or 48-hour dialysis and 48-hour storage at 4 °C. Nonetheless, the biological significance of N-nitrosation of protein lysine is yet to be proven.
Keywords
- Lysine
- N-Nitrosation
- Denitrosation
- Histone
- Peroxynitrite
- Nitric oxide