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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Article
N-nitrosation and denitrosation on lysine residues of histones
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1
Division of Science and Mathematics, Bethune-Cookman College, Daytona Beach, Florida 32114, USA
Front. Biosci. (Landmark Ed) 2004, 9(1), 187–191;
https://doi.org/10.2741/1222
Published: 1 January 2004
Abstract
Increased immunoactivity of ε-nitrosolysine was detected in Western blot in peroxynitrite-reacted histones H2A, H3 and H4. The N-nitrosation may be reversible as indicated by the decreased immunoactivity via either subsequent incubation with reduced glutathione or 48-hour dialysis and 48-hour storage at 4 °C. Nonetheless, the biological significance of N-nitrosation of protein lysine is yet to be proven.
Keywords
Lysine
N-Nitrosation
Denitrosation
Histone
Peroxynitrite
Nitric oxide