IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/claverys

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Extracellular-peptide control of competence for genetic transformation in Streptococcus pneumoniae

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1 Laboratoire de Microbiologie et Génétique Moléculaire, UMR 5100 CNRS-Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
2 Department of Chemistry and Biotechnology, Agricultural University of Norway, PO Box 5040, N-1432, As, Norway
Academic Editor:Peter Zuber
Front. Biosci. (Landmark Ed) 2002, 7(4), 1798–1814;
Published: 1 August 2002
(This article belongs to the Special Issue Prokaryotic transcriptional regulation: beyond the enteric paradigms)

Bacteria, which often are subjected to fluctuations in nutrients, temperature, radiation, pH, etc., adapt to the physico-chemical environment they live in by making the appropriate changes in their gene expression patterns. During the last decades it has become increasingly clear that bacteria, in addition, have a "social life", and that changes in gene expression can also be elicited by the presence of other bacteria. Traditionally bacteria have been viewed as solitary organisms that in general do not interact with other bacteria in a coordinated manner. Recent advances in the field of bacterial cell-to-cell communication has proved this to be a misconception, and mounting evidence now show that bacterial group behaviour is ubiquitous in nature.

Competence for natural genetic transformation in Streptococcus pneumoniae, which has been studied for more than seventy years, has become a paradigm for intercellular communication and cell density dependent regulation of gene expression in Gram-positive bacteria. There has been rapid progress recently in elucidating the molecular mechanisms behind regulation of natural competence in S. pneumoniae. In this review, we describe the current status of our knowledge of natural competence in this bacterium, with particular emphasis on the early phase of competence induction.

Intercellular Communication
Streptococcus Pneumoniae
Competence Stimulating Peptide
Natural Transformation
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