Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
In this article I will discuss the notion that many integrins have similar functions in cell spreading, organization of the cytoskeleton and intracellular signalling. Most of these functions are transmitted through the cytoplasmic domains of integrin beta-subunits. These parts are also quite conserved between most integrins. I will discuss, what is known about the molecules binding to these parts of integrins, and which of those transmit the conserved functions.