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Article
Structure and function of heparin-binding EGF-like growth factor (HB-EGF)
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1
Department of Surgery, Children's Hospital and The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA
Front. Biosci. (Landmark Ed) 1998, 3(4), 288–299;
https://doi.org/10.2741/A241
Published: 1 March 1998
Abstract
Heparin-binding EGF-like growth factor (HB-EGF) is a 22 kDa, O-glycosylated protein that is mitogenic for fibroblasts, smooth muscle cells (SMC) and epithelial cells. This review describes the primary structure of HB-EGF, as well as its processing. The structure of the mouse and human HB-EGF genes is also discussed. Finally, this review summarizes HB-EGF expression patterns, receptor-mediated signaling, and role in several important biological systems.