IMR Press / FBL / Volume 28 / Issue 4 / DOI: 10.31083/j.fbl2804076
Open Access Review
The Roles of Microtubule-Associated Protein 4 in Wound Healing and Human Diseases
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1 Department of Dermatology, Southwest Hospital, Third Military Medical University (Army Medical University), 400038 Chongqing, China
2 Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 400038 Chongqing, China
3 Institute of Wound Repair and Regeneration Medicine, Southern University of Science and Technology School of Medicine, 518071 Shenzhen, Guangdong, China
4 Department of Wound Repair, Southern University of Science and Technology Hospital, 518055 Shenzhen, Guangdong, China
*Correspondence: yshuang1958@163.com (Yuesheng Huang)
Front. Biosci. (Landmark Ed) 2023, 28(4), 76; https://doi.org/10.31083/j.fbl2804076
Submitted: 4 October 2022 | Revised: 20 December 2022 | Accepted: 11 January 2023 | Published: 19 April 2023
(This article belongs to the Special Issue The Role of Microtubule Dynamics in Life Activities)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Microtubules (MTs) are essential structural elements of cells. MT stability and dynamics play key roles in integrity of cell morphology and various cellular activities. The MT-associated proteins (MAPs) are specialized proteins that interact with MT and induce MT assemble into distinct arrays. Microtubule-associated protein 4 (MAP4), a member of MAPs family, ubiquitously expressed in both neuronal and non-neuronal cells and tissues, plays a key role in regulating MT stability. Over the past 40 years or so, the mechanism of MAP4 regulating MT stability has been well studied. In recent years, more and more studies have found that MAP4 affects the activities of sundry human cells through regulating MT stability with different signaling pathways, plays important roles in the pathogenesis of a number of disorders. The aim of this review is to outline the detailed regulatory mechanisms of MAP4 in MT stability, and to focus on its specific mechanisms in wound healing and various human diseases, thus to highlight the possibility of MAP4 as a future therapeutic target for accelerating wound healing and treating other disorders.

Keywords
microtubule
microtubule-associated protein 4
microtubule stability
microtubule dynamics
wound healing
human diseases
Funding
81430042/Key Project of the National Natural Science Foundation of China (NSFC)
2017YFC1103302/National Key Research and Development Program
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