IMR Press / FBL / Volume 28 / Issue 4 / DOI: 10.31083/j.fbl2804066
Open Access Review
Current Advancements and Strategies of Biomaterials for Tendon Repair: A Review
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1 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, 201620 Shanghai, China
2 Department of Chemistry, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia
3 Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, 3122 Boroondara, VIC, Australia
4 Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, Fukuoka-shi, 819-0385 Fukuoka, Japan
5 Department of Biotechnology, Faculty of Science and Technology, University of Central Punjab (UCP), 54000 Lahore, Pakistan
*Correspondence: binbin.sun@dhu.edu.cn (Binbin Sun); shafiq.muhammad.246@m.kyushu-u.ac.jp (Muhammad Shafiq); xmm@dhu.edu.cn (Xiumei Mo)
Front. Biosci. (Landmark Ed) 2023, 28(4), 66; https://doi.org/10.31083/j.fbl2804066
Submitted: 13 December 2022 | Revised: 27 February 2023 | Accepted: 8 March 2023 | Published: 6 April 2023
(This article belongs to the Special Issue Biomaterials in Regenerative Medicine)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Tendon is a bundle of tissue comprising of a large number of collagen fibers that connects muscle to bone. However, overuse or trauma may cause degeneration and rupture of the tendon tissues, which imposes an enormous health burden on patients. In addition to autogenous and allogeneic transplantation, which is commonly used in the clinic, the current research on tendon repair is focused on developing an appropriate scaffold via biomaterials and fabrication technology. The development of a scaffold that matches the structure and mechanics of the natural tendon is the key to the success of the repair, so the synergistic optimization of the scaffold fabrication technology and biomaterials has always been a concern of researchers. A series of strategies include the preparation of scaffolds by electrospinning and 3D printing, as well as the application of injectable hydrogels and microspheres, which can be used individually or in combination with cells, growth factors for tendon repair. This review introduces the tendon tissue structure, the repair process, the application of scaffolds, and the current challenges facing biomaterials, and gives an outlook on future research directions. With biomaterials and technology continuing to be developed, we envision that the scaffolds could have an important impact on the application of tendon repair.

Keywords
tendon repair
scaffolds
biomaterials
electrospinning
3D printing
Funding
81501606/National Natural Science Foundation of China
32050410286/National Natural Science Foundation of China
81771951/National Natural Science Foundation of China
20S31900900/Science and Technology Commission of Shanghai Municipality
20DZ2254900/Science and Technology Commission of Shanghai Municipality
M-0263/Sino German Science Foundation Research Exchange Center
JP21F21353/Grant-in-Aid for JSPS Fellows
RSP2023R65/Researchers Supporting Project
Figures
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