- Academic Editors
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†These authors contributed equally.
Background: Glioma has a high incidence in young and middle-aged adults
and a poor prognosis. Because of late diagnosis and uncontrollable recurrence of
the primary tumor after failure of existing treatments, glioma patients tend to
have a poor prognosis. Recent advances in research have revealed that gliomas
exhibit unique genetic features. Mitogen-activated protein kinase 9 (MAPK9) is
significantly upregulated in mesenchymal glioma spheres and may be a new target
for glioma diagnosis. This study aimed to investigate the potential diagnostic
significance and predictive value of MAPK9 in glioma. Methods:
Paraffin-embedded tumor tissues and paracancerous tissues were collected from 150
glioma patients seen at the General Hospital of Northern Theater Command.
Immunohistochemistry and western blot assays were used to detect the expression
levels of MAPK9. Prognosis and survival analyses were performed using SPSS 26
software for univariate/multivariate analysis and
log-rank analysis. Cellular models were used to assess the effect of MAPK9
overexpression and knockdown in vitro. Results: MAPK9
expression was higher in glioma tissues than in paraneoplastic tissues.
Prognostic and survival analyses revealed that the MAPK9 expression level is an
independent prognostic factor in glioma patients. In addition, overexpression of
MAPK9 significantly promoted the proliferation and migration of primary glioma
cells, possibly via the Wnt/