IMR Press / FBL / Volume 28 / Issue 2 / DOI: 10.31083/j.fbl2802037
Open Access Review
To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway
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1 Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, 453000 Xinxiang, Henan, China
2 Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, 453000 Xinxiang, Henan, China
3 Department of Oncology, The Third Affiliated Hospital of Xinxiang Medical University, 453000 Xinxiang, Henan, China
*Correspondence: (Yongxi Zhang); (Yuhan Hu)
Front. Biosci. (Landmark Ed) 2023, 28(2), 37;
Submitted: 29 October 2022 | Revised: 4 December 2022 | Accepted: 16 December 2022 | Published: 24 February 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal, however, the underlying mechanisms of CRC remain largely unknown. New evidence suggests that the PI3K/AKT/mTOR pathway is closely related to CRC. PI3K/AKT/mTOR is a classical signaling pathway that is involved in a variety of biological processes, such as regulating cellular metabolism, autophagy, cell cycle progression, cell proliferation, apoptosis, and metastasis. Therefore, it plays a crucial role in the occurrence and development of CRC. In this review, we focus on the role of the PI3K/AKT/mTOR pathway in CRC, and its application of to the treatment of CRC. We review the importance of the PI3K/AKT/mTOR signaling pathway in tumorigenesis, proliferation and progression, and pre-clinical and clinical experience with several PI3K/AKT/mTOR pathway inhibitors in CRC.

colorectal cancer
PI3K/AKT/mTOR signaling pathway
U1804173/National Natural Science Foundation of China
YXKC2021044/Henan province young and middle-aged health science and technology innovation talent project
212102310661/Natural Science Foundation of Henan Province
LHGJ20200504/Joint construction project of Henan Medical Science and technology research plan
Fig. 1.
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