- Academic Editor
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†These authors contributed equally.
Background: Hugan Buzure Granule (HBG) is a traditional prescription of
Uygur nationality in China mainly used to treat liver cold, stomachache, spleen
and rib pain, arthralgia, rheumatism and urinary system diseases. Its mechanism
of action in treating acute kidney injury (AKI) continues to remain unconfirmed.
This study’s objective was to investigate the pharmacodynamics and mechanism of
HBG in the management of AKI. Methods: The damage to the kidney tissue
was examined by using H&E (Hematoxylin-eosin) staining. The BUN (Blood Urea
Nitrogen) and Cr (Creatinine) in serum were examined by biochemical kit. The
content of ROS (Reactive oxygen species) in kidney tissue was determined by ROS
frozen section staining, while the amount of MDA (Malondialdehyde), GSH
(Glutathione), and the enzymes of CAT (Catalase) and SOD (Superoxide dismutase)
were assessed by using a biochemical kit. The tissue apoptosis was seen by using
the TUNEL assay. ELISA kit was utilized to assess the content of IL-6,
TNF-