Background: As a chronic degenerative disorder of the central nervous
system that affects both motor and non-motor systems, Parkinson’s disease (PD) is
very complex, and explanations and models are needed to better understand how
dopaminergic neurons are affected and microglia are activated. Methods:
A theoretical protein-RNA recognition code that assumes that the second letter in
codons is compatible with specific amino acids involved in protein-RNA
recognition was used to search for compatibility of human
Announcements
Open Access
Original Research
1-L Transcription in Parkinson's Disease
Jozef Nahalka1,2,*
Show Less
1
Institute of Chemistry, Centre for Glycomics, Slovak Academy of Sciences, Dubravska cesta 9, SK-84538 Bratislava, Slovak Republic
2
Institute of Chemistry, Centre of Excellence for White-Green Biotechnology, Slovak Academy of Sciences, Trieda Andreja Hlinku 2, SK-94976 Nitra, Slovak Republic
*Correspondence: nahalka@savba.sk (Jozef Nahalka)
Front. Biosci. (Landmark Ed) 2023, 28(11), 292;
https://doi.org/10.31083/j.fbl2811292
Submitted: 27 June 2023 | Revised: 20 September 2023 | Accepted: 11 October 2023 | Published: 23 November 2023
(This article belongs to the Special Issue Thinking about RNA-Binding Proteins: Emerging Roles in Human Health and Diseases)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
α-synuclein
bioinformatics method
identified genes
Parkinson's disease
protein-RNA recognition
Funding
2/0064/22/Vedecká grantová agentúra MŠVVaŠ SR a SAV (VEGA)
Figures
Fig. 1.