Academic Editor: Graham Pawelec
Background: Kidneys are among the vital organs of the human body; therefore,
damage from any exogenous/endogenous agent may put human life at risk. Arachis
hypogaea (AH) contains different free radical scavenging flavonoids, stilbenes,
and tannins. This research aimed to elucidate the possible nephroprotective
mechanism of AH methanolic crude extract (AHcr) and n-hexane oil fraction (AHO)
against gentamycin-induced nephrotoxicity. Methods: After the extraction of the
crude oil of the plant, they were tested against a Gentamycin (GM)-treated group of Swiss
Albino mice for their nephroprotective action. Animals were divided into six
(6) equal groups with five (5) animals in each group. These groups were: control
group (0.5 mL normal saline via intraperitoneal -i.p), gentamycin group
(gentamycin 100 mg/kg i.p), Silymarin + gentamycin group (Silymarin 50 mg/kg and
gentamycin 100 mg/kg i.p), plant extract (AHcr1) and gentamycin group (AHcr1 250
mg/kg and gentamycin 100 mg/kg i.p), AHcr2 + gentamycin group (AHcr2; 500 mg/kg
and gentamycin 100 mg/kg i.p) and the hexane oil fraction (AHO) + gentamycin (AHO
1 mL/kg and GM 100 mg/kg i.p). After completion of doses, animals were sacrificed
for the collection of blood to further investigate biochemical changes and
histopathological changes in kidney tissues. Results: Serum creatinine, urea, and
blood urea nitrogen significantly increased (p