IMR Press / FBL / Volume 28 / Issue 1 / DOI: 10.31083/j.fbl2801006
Open Access Review
Lipophagy: Molecular Mechanisms and Implications in Hepatic Lipid Metabolism
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1 College of Pharmacy, Shenzhen Technology University, 518118 Shenzhen, Guangdong, China
2 Jiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In-Vitro Diagnostic Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, 330013 Nanchang, Jiangxi, China
3 College of Chemistry and Chemical Engineering, Jiangxi Science and Technology Normal University, 330013 Nanchang, Jiangxi, China
4 School of Materials and Mechanical & Electrical Engineering, Jiangxi Science and Technology Normal University, 330038 Nanchang, Jiangxi, China
5 Research Centre of Printed Flexible Electronics, School of Materials Science and Engineering, Harbin Institute of Technology, 518055 Shenzhen, Guangdong, China
6 Sauvage Laboratory for Smart Materials, Harbin Institute of Technology, 518055 Shenzhen, Guangdong, China
7 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078 Macau, China
*Correspondence: liujingxin@sztu.edu.cn (Jingxin Liu); zengtx001@aliyun.com (Bin Zeng)
Academic Editor: Jae Man Lee
Front. Biosci. (Landmark Ed) 2023, 28(1), 6; https://doi.org/10.31083/j.fbl2801006
Submitted: 30 September 2022 | Revised: 1 December 2022 | Accepted: 2 December 2022 | Published: 10 January 2023
(This article belongs to the Special Issue Recent Developments and Emerging Trends in Macroautophagy)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

The liver is the most significant metabolic organ in the body and plays an important role in lipid metabolism. Liver lipid metabolism disorders cause hepatic diseases such as hepatitis, hepatic cirrhosis, and hepatoma. Autophagy is a process of generating energy and building blocks by degrading redundant or damaged proteins and organelles. Thus, it helps in the maintenance of cellular homeostasis. Recent discoveries revealed that lipophagy plays a vital role in hepatic cellular homeostasis and lipid metabolism. Its imbalance is always associated with the perturbation of lipid metabolism in the liver. This article reviewed the molecular mechanisms involved in lipophagy and the interaction between lipophagy and hepatic lipid metabolism. Increasing evidence suggests that lipophagy is an effective method to resolve liver diseases.

Keywords
autophagy
lipophagy
liver
lipid metabolism
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