†These authors contributed equally.
Academic Editor: Iain Hargreaves
This is an open access article under the CC BY 4.0 license.
Background: Cardiovascular disease is associated with high morbidity
and mortality. Doxorubicin (DOX) is an effective adjunct to cancer chemotherapy
but leads to cardiovascular-related side effects. Because coenzyme Q10 (CoQ10)
has been shown to protect against cardiac damage, this study was conducted to
investigate the protective effects of CoQ10 against cardiac damage in mice.
Methods: We randomly divided six-week-old male C57BL/6 mice into four
groups: control (n = 7), CoQ10 (n = 7), heart failure (HF) (n = 7), and HF+CoQ10
(n = 6) groups. HF group was induced via intraperitoneal injections with DOX (5
mg/kg) once weekly for 4 weeks. CoQ10 was solube in corn oil. The mice of CoQ10
and HF+CoQ10 group were given CoQ10 (100 mg/kg) once a day for 8 weeks. All mice
were subjected to different treatment regimens for eight weeks. Metabolic
characteristics, cardiac damage, oxidative stress markers (SIRT1, SIRT3, eNOS,
TE, P53, SIRT5, CAT, HO-1, and SOD), energy metabolism markers (PARP-1 and