IMR Press / FBL / Volume 27 / Issue 8 / DOI: 10.31083/j.fbl2708244
Open Access Original Research
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice
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1 Department of Cardiology, Central Hospital of Dalian University of Technology, 116033 Dalian, Liaoning, China
2 Department of Central Laboratory, Central Hospital of Dalian University of Technology, 116033 Dalian, Liaoning, China
3 Department of Internal Medicine, Affiliated Zhong Shan Hospital of Dalian University, 116001 Dalian, Liaoning, China
*Correspondence: (Shijun Li)
These authors contributed equally.
Academic Editor: Iain Hargreaves
Front. Biosci. (Landmark Ed) 2022, 27(8), 244;
Submitted: 19 May 2022 | Revised: 1 July 2022 | Accepted: 21 July 2022 | Published: 15 August 2022
(This article belongs to the Special Issue Secondary Coenzyme Q10 Deficiencies)
Copyright: © 2022 The Author(s). Published by IMR Press.

This is an open access article under the CC BY 4.0 license.


Background: Cardiovascular disease is associated with high morbidity and mortality. Doxorubicin (DOX) is an effective adjunct to cancer chemotherapy but leads to cardiovascular-related side effects. Because coenzyme Q10 (CoQ10) has been shown to protect against cardiac damage, this study was conducted to investigate the protective effects of CoQ10 against cardiac damage in mice. Methods: We randomly divided six-week-old male C57BL/6 mice into four groups: control (n = 7), CoQ10 (n = 7), heart failure (HF) (n = 7), and HF+CoQ10 (n = 6) groups. HF group was induced via intraperitoneal injections with DOX (5 mg/kg) once weekly for 4 weeks. CoQ10 was solube in corn oil. The mice of CoQ10 and HF+CoQ10 group were given CoQ10 (100 mg/kg) once a day for 8 weeks. All mice were subjected to different treatment regimens for eight weeks. Metabolic characteristics, cardiac damage, oxidative stress markers (SIRT1, SIRT3, eNOS, TE, P53, SIRT5, CAT, HO-1, and SOD), energy metabolism markers (PARP-1 and PPAR-γ), myocardial fibrosis markers (Smad3 and TGF-β), and apoptosis markers (BAK, BCL-XL, and caspase-8) were analyzed at eight weeks after the different treatments. Results: CoQ10 reduced the levels of molecules related to cardiac damage, oxidative stress, energy metabolism, and myocardial fibrosis in mice with doxorubicin-induced HF. CoQ10 also exerted anti-apoptotic effects in HF mice. Conclusions: CoQ10 may be useful for preventing cardiac damage in DOX-induced HF.

heart failure
coenzyme Q10
cardiac damage
BW20220302/Beijing Jiekai Cardiovascular Health Foundation
Fig. 1.
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