Academic Editor: Agnieszka Paradowska-Gorycka
Background: To investigate the synergic effect and underlying mechanism
of Endostar, a recombinant human endostatin used for anti-angiogenesis, in
radiotherapy for cervical cancer. Methods: The Cell Counting Kit-8
(CCK-8) assay and plate cloning experiment were first employed to analyze the
proliferation of HeLa and SiHa cervical cancer cells and human umbilical vein
vascular endothelial cells (HUVECs). Flow cytometry was used to detect apoptosis
and cell cycle progression. A tube formation assay was used to assess
angiogenesis in vitro. The expression of gamma H2A histone family member
X (