IMR Press / FBL / Volume 27 / Issue 8 / DOI: 10.31083/j.fbl2708227
Open Access Original Research
Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma
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1 Department of Forensic Medicine and Toxicology, School of Medicine, Urmia University of Medical Sciences, 5714783734 Urmia, Iran
2 Center for Molecular Biosciences (CMBI), Institute of Pharmacy/Pharmacognosy, University of Innsbruck, 6020 Innsbruck, Austria
3 Department of Biology, Payame Noor University, 19395-4697 Tehran, Iran
4 Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, 13944-91388 Mashhad, Iran
5 Industrial Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, 9177948974 Mashhad, Iran
6 Medical Toxicology Research Centre, Mashhad University of Medical Sciences, 917794-8564 Mashhad, Iran
7 Applied Biomedical Research Center, Mashhad University of Medical Sciences, 917794-8564 Mashhad, Iran
8 Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, 20133 Milan, Italy
9 Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20133 Milan, Italy
10 National Interuniversity Consortium of Materials Science and Technology (INSTM), 50121 Firenze, Italy
*Correspondence: (Mohammad Ehsan Taghavizadeh Yazdi); (Marcello Iriti)
Academic Editor: Graham Pawelec
Front. Biosci. (Landmark Ed) 2022, 27(8), 227;
Submitted: 28 April 2022 | Revised: 23 May 2022 | Accepted: 30 June 2022 | Published: 25 July 2022
(This article belongs to the Special Issue Bioactive Phytochemicals and Botanicals in Health and Disease)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions. Methods: The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential. Results: The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2). Conclusions: The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Further in vivo investigations is proposed to be designed to assess anti-cancer and safety effects of fabricated nanocomposites.

cerium oxide
green synthesis
cell toxicity
Fig. 1.
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