Academic Editor: Marcello Iriti
Introduction: Boesenbergia rotunda is a famous
culinary/medicinal herb native to Southeast Asia region and it is traditionally
used in the treatment of several diseases. This study investigated the
anti-diabetic properties of Boesenbergia rotunda polyphenol extract
(BRE) in high fructose/streptozotocin-induced diabetic rats. Method: The
in vitro antioxidant activity was evaluated using DPPH and ABST
colorimetric assays, while the Folin-Ciocalteu method was used for the total
phenolic content of BRE. For diabetes induction, a combination of high fructose
solution and streptozotocin was administered to the rats and diabetic rats were
orally administrated with BRE (100 and 400 mg/kg) for 5 weeks. The fasting blood
glucose, body weight gain, food and water consumption were determined during the
treatment period. Results: BRE showed excellent in vitro DPPH
and ABTS scavenging activity with high phenolic content. BRE significantly
lowered fasting blood glucose level, HbA1c, lipid profile, hepatorenal
biochemical parameters and ameliorated the IPGTT in diabetic rats. Additionally,
BRE reversed body weight loss, attenuated food and water intake, serum insulin
level, pancreatic