IMR Press / FBL / Volume 27 / Issue 6 / DOI: 10.31083/j.fbl2706196
Open Access Review
Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations
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1 Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
2 Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA 70112, USA
3 Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
4 Department of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA
5 UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*Correspondence: (Khoa Nguyen); (Matthew E. Burow)
These authors contributed equally.
Academic Editor: Guan Chen
Front. Biosci. (Landmark Ed) 2022, 27(6), 196;
Submitted: 2 January 2022 | Revised: 1 February 2022 | Accepted: 16 February 2022 | Published: 17 June 2022
(This article belongs to the Special Issue MAPKs and Oncogenesis)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have been extensively studied in various disease processes, MAP3K19 is an understudied kinase whose activities have been linked to lung disease and fibroblast development. In this manuscript, we use bioinformatics databases starBase, GEPIA, and KMPlotter, to establish baseline expressions of MAP3K19 in different tissue types and its correlation with patient survival in different cancers.

understudied kinase
dark kinome
MAPK signaling
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