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MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
Khoa Nguyen1,*,†, Minh N. Tran1,†, Andrew Rivera1, Thomas Cheng1, Gabrielle O. Windsor1, Abraham B. Chabot1, Jane E. Cavanaugh2, Bridgette M. Collins-Burow1, Sean B. Lee3, David H. Drewry4, Patrick T. Flaherty2, Matthew E. Burow1,*
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1
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
2
Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA
3
Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
4
UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, Chemical Biology and Medicinal Chemistry Division, SGC-UNC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*Correspondence: knguyen11@tulane.edu (Khoa Nguyen); mburow@tulane.edu (Matthew E. Burow)
†These authors contributed equally.
Academic Editors: Guan Chen and Graham Pawelec
†These authors contributed equally.
Academic Editors: Guan Chen and Graham Pawelec
Front. Biosci. (Landmark Ed) 2022, 27(5), 167;
https://doi.org/10.31083/j.fbl2705167
Submitted: 1 January 2022 | Revised: 14 February 2022 | Accepted: 24 February 2022 | Published: 23 May 2022
(This article belongs to the Special Issue MAPKs and Oncogenesis)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.
Keywords
MAP kinases
MAPK
MAP3K
understudied kinase
Dark Kinome
Illuminating the Druggable Genome
cancer