†These authors contributed equally.
§On behalf of the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF).
Academic Editors: Massimo Conese and Lorenzo Guerra
Background: People with Cystic Fibrosis (CF) develop pulmonary
inflammation, chronic infection and structural lung damage early in life, with
these manifestations being prevalent among preschool children and infants. While
early immune events are believed to play critical roles in shaping the
progression, severity and disease burden later in life, T cells and their subsets
are poorly studied in the CF lung, particularly during the formative early stages
of disease. Methods: Using flow cytometry, we analyzed Mucosal
Associated Invariant T (MAIT) cells,