Academic Editor: Amancio Carnero Moya
Background: Cancer is a representative geriatric disease closely
related to senescent cells and cell aging in tissues. Senescent cells that
surround cancer tissues reduce the effects of various cancer treatments and
induce cancer recurrence through senescence-associated secretory phenotype (SASP)
secretion. Thus, for good therapeutic effect, candidate drugs should be selective
for both cancer and senescent cells. In this study, we investigated the selective
effect of piperine as a potential senostatic agent as well as an anticancer drug.
Methods: The effect of piperine on cytotoxicity and cell proliferation
was tested by lactate dehydrogenase (LDH) or water-soluble tetrazolium salt (WST)
assay. The levels of p16