†These authors contributed equally.
Academic Editor: Graham Pawelec
Backgrounds: Dental avulsion due to trauma, especially in young
patients, is a worldwide problem, requiring tooth replacement. Delayed
replantation could cause tooth loss when the cementum is severely damaged. A
small number of studies has reported that photobiomodulation (PBM) therapy using
Er: YAG laser irradiation activates cellular signaling responses in different
cell types, resulting in a variety of favorable biological effects. The aim of
this in vitro study was to evaluate the potential biostimulatory effect
of low-level Er: YAG laser irradiation on the biological responses of cultured
mouse cementoblasts (OCCM-30), including the mitogen-activated protein kinases
(MAPKs). Methods: OCCM-30 cells were exposed to 2940 nm Er: YAG laser
irradiation for 15 s at 0.34 W (pulse duration of 100 or 1000