Announcements
Open Access
Review
A Critical Role for CARD9 in Intestinal Microbiota Modulation and Colorectal Malignancies
Show Less
1
Department of Breast Surgery, Nanchang Third Hospital, 330000 Nanchang, Jiangxi, China
2
Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China
3
Department of Pharmacy, Shanghai Songjiang District Central Hospital, 201600 Shanghai, China
*Correspondence: zizhen.ming@shsmu.edu.cn (Zizhen Ming); yangzhiwen2009@sina.com (Zhiwen Yang)
Academic Editors: Mario Scartozzi, Eleonora Lai, Andrea Pretta and Dario Spanu
Academic Editors: Mario Scartozzi, Eleonora Lai, Andrea Pretta and Dario Spanu
Front. Biosci. (Landmark Ed) 2022, 27(12), 320;
https://doi.org/10.31083/j.fbl2712320
Submitted: 3 September 2022 | Revised: 6 November 2022 | Accepted: 14 November 2022 | Published: 7 December 2022
(This article belongs to the Special Issue Advances in Gastrointestinal Cancer Research)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
The adaptor protein Caspase Recruitment Domain Family Member 9 (CARD9) plays an indispensable role in innate immunity. Recent studies indicate that dysregulated CARD9 is a critical risk factor in the progression of colorectal cancer (CRC). This review provides novel insights into the functions of CARD9 in CRC, particularly in delineating its role in disrupting the host microbe balance, fueling gut microbiota metabolism and inducing systemic immunoglobulin G (IgG) antifungal antibodies. These pathways provide important information that can potentially be used for therapeutic innovation in developing potential vaccines for CRC.
Keywords
CARD9
colorectal cancer
gut microbe
microbiota metabolism
systemic antifungal antibodies
Figures
Fig. 1.