IMR Press / FBL / Volume 27 / Issue 11 / DOI: 10.31083/j.fbl2711309
Open Access Original Research
Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility
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1 Huzhou Third Municipal Hospital, The Affiliated Hospital of Wenzhou Medical University, 313000 Huzhou, Zhejiang, China
2 Laboratory of Translational Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, 315300 Ningbo, Zhejiang, China
3 School of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, China
4 School of Pharmacy, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, China
5 Beijing Hui-Long-Guan Hospital, Peking University, 100096 Beijing, China
6 Key Laboratory of Psychosomatic Medicine, Inner Mongolia Medical University, 010110 Hohhot, Inner Mongolia, China
7 The Affiliated Kangning Hospital, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, China
*Correspondence: (Yanlong Liu); (Fan Wang); (Li Chen)
These authors contributed equally.
Academic Editor: Maria Pina Concas
Front. Biosci. (Landmark Ed) 2022, 27(11), 309;
Submitted: 11 August 2022 | Revised: 25 October 2022 | Accepted: 26 October 2022 | Published: 17 November 2022
(This article belongs to the Special Issue Genetics of Psychiatric Disorders)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background and Aims: Nicotine dependence (ND)-induced anxiety might be modulated by genetic polymorphisms. The gene-by-environment interaction can be fitted into the diathesis-stress and differential susceptibility models. Nevertheless, knowledge of the interaction between adiponectin (ADPN) polymorphisms and ND on the incident mental disorder is currently scarce. This study aims to understand the role of ADPN rs266729 on anxiety in patients with ND while elucidating the psychology model and the various reactions across genotypes. Methods: We included 315 Chinese males with confirmed ND, measured using the Fagerstrom test for nicotine dependence (FTND). Anxiety was assessed using the Self-rating Anxiety Scale. Genomic DNA was extracted and genotyped from peripheral blood. Hierarchical regression models were used to test the interactions. Results: There was a significant interaction between ADPN rs266729 and ND (β = –0.19, p < 0.05). The CC homozygote was more likely to be affected by ND-induced anxiety (β = 0.14, t = 4.43, p < 0.01). Re-parameterized regression models revealed that the interaction between ADPN rs266729 and ND could fit the strong differential susceptibility model (R2 = 0.05, p < 0.001). Conclusions: ADPN rs266729 was correlated with susceptibility to anxiety symptoms among male adults with ND and could fit the differential susceptibility model. The CC homozygote of rs266729 was a plasticity factor that increased anxiety symptoms in individuals with ND.

nicotine dependence (ND)
differential susceptibility
2018D01C239/Natural Science Foundation of Xinjiang Uyghur Autonomous Region
2019KY681/Project of Health Department in Zhejiang Province
2018GY20/Huzhou Municipal Science and Tech Commission
Fig. 1.
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