IMR Press / FBL / Volume 26 / Issue 4 / DOI: 10.2741/4915

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation
Show Less
1 Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
2 Amity Institute of Biotechnology, Amity University, Sector 125, NOIDA, Uttar Pradesh 201313, India
3 Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
4 Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
5 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
6 ICMR Headquaters, New Delhi, India
Front. Biosci. (Landmark Ed) 2021, 26(4), 717–743; https://doi.org/10.2741/4915
Published: 1 October 2020
(This article belongs to the Special Issue Elucidation of exosomes role in metastasis)
Abstract

Implantation in humans is a multistep process that involves apposition, adhesion, and invasion of the developing blastocyst into the receptive maternal endometrium. Though significant volume of research in this direction has identified important players orchestrating this delicate process, there are still gaps in our understanding of all the sequence of events during embryo implantation. Also, the early pregnancy-related complications that lead to fetal loss and miscarriage often occur in this critical window of implantation, which is primarily defined as the time when the maternal endometrium is supposed to be most receptive to the free blastocyst that emerges out from the zona pellucida. Studies in humans and rodents have identified several mediators like folliculin, LIF, IL11Rα, splicing factor SC35, etc. to be essential for early implantation. Trophoblasts, that form the outer epithelial layer of the blastocyst, participate in the formation of the placenta. During placentation, invasive extravillous trophoblasts (EVTs), migrate into the endometrium, and a transient epithelial to mesenchymal transition (EMT) and remodel the uterine arteries for blood and nutrient exchange.

Keywords
Trophoblast invasion
EMT
Pseudomalignant
Proteases
feto-Maternal interface
Review
Figures
Figure 1
Share
Back to top