IMR Press / FBL / Volume 26 / Issue 4 / DOI: 10.2741/4912

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
ITGBL1 promotes gastric cancer cell proliferation and invasion via Akt signal pathway
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1 Department of Thyroid Surgery, Taian Central Hospital, Taian, Shandong,271000, China
2 Department of Oncology; Taian Central Hospital, Taian, Shandong,271000, China
3 Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, Shandong,271000, China
4 Department of Endocrinology; Taian Central Hospital, Taian, Shandong,271000, China
Front. Biosci. (Landmark Ed) 2021, 26(4), 682–691; https://doi.org/10.2741/4912
Published: 1 October 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Integrin beta- like 1 (ITGBL1), an extracellular matrix protein, plays an oncogenic role in diverse forms of cancers. To this end, we examined the importance of ITGBL1 in gastric cancer (GC). The upregulated expression of ITGBL1 in GC was associated with a poor prognosis. Moreover, upregulation of ITGBL1 enhanced cell mobility while silencing it exerted an opposite effect. Up-regulation of ITGBL1 significantly promoted phosphorylation of Akt, decreased the ratio of phosphorylated Akt in AGS/ITGBL1-shRNA and N87/ITGBL1-shRNA cells, enhanced cell mobility and proliferation. Silencing ITGBL1 had an opposite effect on Akt phosphorylation, cell mobility, and proliferation. These findings show that ITGBL1 regulates mobility and proliferation of GC likely through activation of Akt signaling.

Keywords
ITGBL1
Akt signaling
Gastric cancer
Cell proliferation
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