IMR Press / FBL / Volume 26 / Issue 3 / DOI: 10.2741/4905

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review
Diagnostic and therapeutic applications of smart nanocomposite dendrimers
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1 Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan 305817, India
Send correspondence to: Amit K. Goyal, Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan-305817, India, Tel: 91-1463 238728, Fax: 91-1463 238728, E-mail: amit.goyal@curaj.ac.in
Front. Biosci. (Landmark Ed) 2021, 26(3), 518–538; https://doi.org/10.2741/4905
Published: 1 October 2020
Abstract

Dendrimers are three dimensional, multifunctional polymeric structures which are composed of a core and branches emanating from these structures, resembling a tree. Here, we review the key highlights of the dendrimers for diagnostic uses as MRI contrast agents, X-ray computed tomography and particularly for cancer treatment as an effective carrier for drug delivery and in boron capture therapy. We will discuss how dendrimers represent a new class of carriers that are able to deliver drugs effectively and in a sustained manner to the target tumor sites. Dendrimers are being utilized to a variety of cancer therapies to improve the safety and effectiveness of anticancer therapeutics. This review will also investigates the benefits utilizing dendrimers for cancer diagnosis and therapy.

Keywords
Dendrimers
PAMAM
Contrast agents
Biomedical applications
Nanotechnology
Review
Figures
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