IMR Press / FBL / Volume 26 / Issue 3 / DOI: 10.2741/4904

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Optimum health and inhibition of cancer progression by microbiome and resveratrol
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1 Cancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, AL 36101
2 Department of Zoology, University of Lucknow, Lucknow, 226007, India
3 Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, 30310
4 Department of Pathology, University of Alabama Birmingham, Birmingham, AL 35294
5 Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322
Send correspondence to: Manoj Mishra, Cancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, AL 36104, USA, Tel: 334-604-8410, Fax: 334-229-5035, E-mail: mmishra@alasu.edu
Front. Biosci. (Landmark Ed) 2021, 26(3), 496–517; https://doi.org/10.2741/4904
Published: 1 October 2020
(This article belongs to the Special Issue Recent progress in reproductive biology)
Abstract

Resveratrol (RES) is a naturally occurring polyphenol found in fruits, green leafy vegetables, and peanuts. This versatile compound, which has potent regenerative, anti-oxidative, and cancer-fighting properties, is produced in plants, particularly in response to stress stimuli. By various mechanisms, including regulation of genes and proteins, RES inhibits the growth of pathogenic bacteria and the development of cancers. The gut has a prominent role in nutrient assimilation, metabolism, immunity, and cancer regression, and the endogenous microbiome protects the host from invasive bacteria that facilitate the progression of various diseases. Short-chain fatty acids (SFCAs) are the byproducts of microbial fermentation in the gastrointestinal tract. Native microflora regulates internal homeostasis, influence the activity of host immune cells, and regress some cancers via the action of SCFAs produced from a plant-based diet. This review shows the relevance of dietary constituents and gut microbial activity in ensuring optimal health of the host.

Keywords
Resveratrol
RES
short-chain fatty acids
SCFAs
Heat shock proteins
HSPs
Cancer
Microbiome
Microbiota
Review
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