IMR Press / FBL / Volume 26 / Issue 3 / DOI: 10.2741/4901

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Crosstalk between CML cells with HUVECs and BMSCs through exosomes
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1 Department of Medical Biology, School of Medicine, Sanko University, Gaziantep, Turkey
2 Department of Biological and Biomedical Sciences, Graduate Education Institute, Sanko University, Gaziantep, Turkey
3 Department of Medical Biochemstry School of Medicine, Sanko University, Gaziantep, Turkey
4 Department of Molecular Medicine, Graduate Education Institute, Sanko University, Gaziantep, Turkey
5 Department of Internal Medicine and Hematology, Sanko University Sani Konukoglu Application and Research Hospital, Gaziantep, Turkey
Front. Biosci. (Landmark Ed) 2021, 26(3), 444–467; https://doi.org/10.2741/4901
Published: 1 October 2020
(This article belongs to the Special Issue Oxidative stress, DNA damage and inflammation in carcinogenesis)
Abstract

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein. Imatinib is first FDA approved first-line BCR-ABL targeting drug for the treatment of newly diagnosed CML cases. Nowadays there are recently developed and more efficient TKIs in the market. Despite the improvements in the CML therapy by using tyrosine kinase inhibitors (TKIs) primary/secondary resistance or progression from chronic to accelerated and blastic phase may be developed in some cases. Underlying mechanisms of TKI resistance and disease progression may results from BCR/ABL dependent or independent alterations. Recently it was revealed that tumor microenvironment is very important for cancer cell growth, survival, proliferation, hemostasis, invasion and metastasis. Exosomes derived from tumor cells contain many important signaling molecules and transfer these molecules in the neighbouring cells. In the bone marrow matrix CML cells, CML leukemic stem cells,cells, bone marrow mesenchymal stromal cells can communicate with each other through exosomes. In this review we focused on biological and clinical importance of CML derived exosomes and we will summarize the recent studies in this field.

Keywords
Chronic myeloid leukemia
CML
Exosomes
mi-RNA
angiogenesis
adhesion
migration
drug resistance
bone marrow mesenchymal stromal cells
BMSCs
CML leukemia stem cells
Review
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