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Research progress in gene editing technology
Sheng Huang1,2,†, Yali Yan2,†, Fei Su1,2, Xiaorui Huang1,2, Dandan Xia1,2, Xinxin Jiang1,2, Yinghui Dong1,2, Ping Lv1,2, Fangyuan Chen1,2, Yanwei Lv3,*
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1
Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Science, Shandong Normal University, 250014 Jinan, Shandong, China
2
Bellagen Biotechnology Co., Ltd., 250000 Jinan, Shandong, China
3
College of Life Sciences, Liaocheng University, 252000 Liaocheng, Shandong, China
*Correspondence: lvyanwei@lcu.edu.cn (Yanwei Lv)
† These authors contributed equally.
† These authors contributed equally.
Front. Biosci. (Landmark Ed) 2021, 26(10), 916–927;
https://doi.org/10.52586/4997
Submitted: 1 May 2021 | Revised: 17 August 2021 | Accepted: 24 August 2021 | Published: 30 October 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
As a tool for modifying the genome, gene editing technology has developed rapidly in recent years, especially in the past two years. With the emergence of new gene editing technologies, such as transposon editing tools, numerous advancements have been made including precise editing of the genome, double base editing, and pilot editing. This report focuses on the development of gene editing tools in recent years, elaborates the progress made in classic editing tools, base editor and other new editing tools, and provides insights into challenges and opportunities.
Keywords
Gene editing
Base editing
Transposons
New tools
Figures
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