Objective: Nucleus
pulposus cells (NPCs) are cells extracted from the intervertebral disc and are
important for research into intervertebral disc degeneration (IVDD). NPCs live in
an avascular and relatively hypoxic environment. Cobalt chloride (CoCl
Announcements
Open Access
Original Research
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro
Xiao-Xin Gao1, Chen-Hao Liu1, Zhi-Lei Hu1, Hai-Yin Li1, Xian Chang1, Yue-Yang Li1, Yu-Yao Zhang1, Yu Zhai1, Chang-Qing Li1,*
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1
Department of Orthopedics, Xinqiao Hospital, Army Military Medical University, 400037 Chongqing, China
*Correspondence: changqli1970@126.com (Chang-Qing Li)
Front. Biosci. (Landmark Ed) 2021, 26(10), 799–812;
https://doi.org/10.52586/4989
Submitted: 21 July 2021 | Revised: 2 September 2021 | Accepted: 7 September 2021 | Published: 30 October 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Nucleus pulposus cells
Cobalt chloride
Hypoxia
Apoptosis
Migration
Extracellular matrix synthesis
Figures
Fig. 1.