IMR Press / FBL / Volume 26 / Issue 1 / DOI: 10.2741/4890

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

From genoprotection to rejuvenation

Show Less
1 Frontiers in Bioscience Research Institute in Aging and Cancer, 16471 Scientific Way, Irvine, CA, USA
Front. Biosci. (Landmark Ed) 2021, 26(1), 97–162; https://doi.org/10.2741/4890
Published: 1 October 2020
Abstract

Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient sensors including AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), the insulin/insulin-like IIGF) growth factor signaling pathway (IIS), sirtuins, NFκB, and FOXO. Aging can be delayed and life-span and health-span can be extended by calorie and dietary restrictions, administration of NAM, NMN, NR, NAD+, and by antioxidants including hydrogen sulfide. Additional measures for the age related decline in tissue homeostasis include senotherapeutics, senolytics, senomorphics, anti-inflammaging strategies, reactivation of telomerase and prevention of stem cell exhaustion. There is also a possibility to erase the signs of aging and even to reverse aging by epigenetic reprogramming and other emerging measures.

Keywords
Aging
Senescence
Immunosenescence
Treatment
Senotherapeutics
Senolytics
Senomorphics
Anti-Inflammaging
Aging Reversal
Review
Share
Back to top