IMR Press / FBL / Volume 25 / Issue 9 / DOI: 10.2741/4875

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Progression of squamous cell carcinoma is regulated by miR-139-5p/CXCR4
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1 Department of Oral Surgery, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, P. R. China
2 Department of Pediatric Dentistry, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, P. R. China
3 Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, P. R. China
Front. Biosci. (Landmark Ed) 2020, 25(9), 1732–1745; https://doi.org/10.2741/4875
Published: 1 June 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

miR-139-5p has a tumor suppressor effect in some cancers and negatively regulates CXCR4. To this end, we examined the expression and mechanism of of action of miR-139-5p and CXCR4 in oral squamous cell carcinoma (OSCC). miRNA-139-5p was down-regulated whereas CXCR4 was increased in tissues and cells of OSCC. Moreover, low expression of miR-139-5p was associated with a low survival. Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4. The inverse relation between expression of miR-139-5p and CXCR4 might be related to the fact that miR-139-5p negatively regulates CXCR4 expression by virtue of direct binding. These findings underscore the importance of miR-139-5p and CXCR4 in regulation of OSCC.

Keywords
Oral
Squamous Cell Carcinoma
miR-139-5p
Wnt
Beta-Catenin Signaling
Proliferation
Invasion
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