IMR Press / FBL / Volume 25 / Issue 9 / DOI: 10.2741/4874

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease
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1 Department of Anatomy and Histology and Embryology, Capital Medical University, Beijing, China
2 Department of Experimental Center for Basic Medical Teaching, Capital Medical University, Beijing, China
Send correspondence to: Yan Gao, Department of Anatomy and Histology and Embryology, Capital Medical University, No. 10 Xitoutiao, Youanmanwai, Fengtai district, Beijing 100069, China, Tel: 86-10-83911452, Fax: 86-10-83911452, E-mail: gy1003@ccmu.edu.cn
Front. Biosci. (Landmark Ed) 2020, 25(9), 1718–1731; https://doi.org/10.2741/4874
Published: 1 June 2020
(This article belongs to the Special Issue Precision neurology)
Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by abnormal alpha-synuclein aggregation and Lewy body formation, which leads to neurodegeneration and dopaminergic cell death. Currently there is no cure for PD. Thus, it is imperative to develop a new therapeutic approach. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a member of unconventional evolutionary conserved protein families. It has unique molecular structure and capable to detect and rescue apoptotic neurons. MANF protein could selectively enhance the survival and sprouting of nigral dopaminergic neurons in vitro. Studies have shown that MANF can protect and repair dopaminergic neurons in animal models of PD. MANF is localized in the endoplasmic reticulum (ER) lumen function in regulation of ER stress and unfolded protein responses. Its C terminal domain is complete homologous to SAP domain of Ku70, which functions in anti-apoptosis. In this review, we described molecular structure, tissue expression of MANF, and summarized preclinical studies using MANF for PD therapy. We also discussed the mechanisms of MANF for the treatment of PD.

Keywords
Mesencephalic astrocyte-derived neurotrophic factor
Dopaminergic neuron
Parkinson’s disease
Review
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