IMR Press / FBL / Volume 25 / Issue 7 / DOI: 10.2741/4854

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Intracellular transports and atherogenesis
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1 Department of Cell Biology, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy
2 Department of Anatomy, Ivanovo State Medical Academy, Ivanovo, Russia
3 Department of Anatomy, Saint Petersburg State Pediatric Medical University. S. Petersburg, Russia
Front. Biosci. (Landmark Ed) 2020, 25(7), 1230–1258; https://doi.org/10.2741/4854
Published: 1 March 2020
(This article belongs to the Special Issue New trends in atherosclerosis research)
Abstract

There is a great progress in understanding the cellular and molecular aspects of atherosclerosis, which is one of the leading causes of death. Yet, there are questions regarding the cellular and metabolic mechanisms that lead to atherogenesis. Among the many factors that influence this process, food plays a significant role. Among other factors that play a paramount role in atherogensis are alterations of the transport of food in enterocytes, oxysterols, development of an atherogenic serum, endothelial damage, accumulation of foam cells within the vessel wall, lysosome-ER transport, and hypertension. Here, we discuss the contribution of secretion, transcytosis, endocytosis of chylomicrons, low-density lipoproteins (LDL), very LDL, and high-density lipoproteins to atherogenesis.

Keywords
Atherosclerosis
LDL
HDL
VLDL
Transcytosis
Endothelial Cell
Chylomicron; Intima
Foam Cell
Lysosome
Review
Figures
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